Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies
Identifieur interne : 000184 ( Main/Exploration ); précédent : 000183; suivant : 000185Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies
Auteurs : Yaoqing Chen [États-Unis] ; Teddy John Wohlbold [États-Unis] ; Nai-Ying Zheng [États-Unis] ; Min Huang [États-Unis] ; Yunping Huang [États-Unis] ; Karlynn E. Neu [États-Unis] ; Jiwon Lee [États-Unis] ; Hongquan Wan [États-Unis] ; Karla Thatcher Rojas [États-Unis] ; Ericka Kirkpatrick [États-Unis] ; Carole Henry [États-Unis] ; Anna-Karin E. Palm [États-Unis] ; Christopher T. Stamper [États-Unis] ; Linda Yu-Ling Lan [États-Unis] ; David J. Topham [États-Unis] ; John Treanor [États-Unis] ; Jens Wrammert [États-Unis] ; Rafi Ahmed [États-Unis] ; Maryna C. Eichelberger [États-Unis] ; George Georgiou [États-Unis] ; Florian Krammer [États-Unis] ; Patrick C. Wilson [États-Unis]Source :
- Cell [ 0092-8674 ] ; 2018.
Abstract
Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly display key NA epitopes and rarely induce NA-reactive B cells. Conversely, influenza virus infection induces NA-reactive B cells at a frequency that approaches (H1N1) or exceeds (H3N2) that of HA-reactive B cells. NA-reactive antibodies display broad binding activity spanning the entire history of influenza A virus circulation in humans, including the original pandemic strains of both H1N1 and H3N2 subtypes. The antibodies robustly inhibit the enzymatic activity of NA, including oseltamivir-resistant variants, and provide robust prophylactic protection
Url:
DOI: 10.1016/j.cell.2018.03.030
PubMed: 29625056
PubMed Central: 5890936
Affiliations:
- États-Unis
- Géorgie (États-Unis), Illinois, Maryland, Texas, État de New York
- Austin (Texas), Chicago
- Université de Chicago, Université du Texas à Austin
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies</title><author><name sortKey="Chen, Yaoqing" sort="Chen, Yaoqing" uniqKey="Chen Y" first="Yaoqing" last="Chen">Yaoqing Chen</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Wohlbold, Teddy John" sort="Wohlbold, Teddy John" uniqKey="Wohlbold T" first="Teddy John" last="Wohlbold">Teddy John Wohlbold</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zheng, Nai Ying" sort="Zheng, Nai Ying" uniqKey="Zheng N" first="Nai-Ying" last="Zheng">Nai-Ying Zheng</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Huang, Min" sort="Huang, Min" uniqKey="Huang M" first="Min" last="Huang">Min Huang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Huang, Yunping" sort="Huang, Yunping" uniqKey="Huang Y" first="Yunping" last="Huang">Yunping Huang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Neu, Karlynn E" sort="Neu, Karlynn E" uniqKey="Neu K" first="Karlynn E." last="Neu">Karlynn E. Neu</name><affiliation wicri:level="4"><nlm:aff id="A3">The Committee on Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Committee on Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Lee, Jiwon" sort="Lee, Jiwon" uniqKey="Lee J" first="Jiwon" last="Lee">Jiwon Lee</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78731, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78731</wicri:regionArea><placeName><region type="state">Texas</region><settlement type="city">Austin (Texas)</settlement></placeName><orgName type="university">Université du Texas à Austin</orgName></affiliation></author><author><name sortKey="Wan, Hongquan" sort="Wan, Hongquan" uniqKey="Wan H" first="Hongquan" last="Wan">Hongquan Wan</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Rojas, Karla Thatcher" sort="Rojas, Karla Thatcher" uniqKey="Rojas K" first="Karla Thatcher" last="Rojas">Karla Thatcher Rojas</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Kirkpatrick, Ericka" sort="Kirkpatrick, Ericka" uniqKey="Kirkpatrick E" first="Ericka" last="Kirkpatrick">Ericka Kirkpatrick</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Henry, Carole" sort="Henry, Carole" uniqKey="Henry C" first="Carole" last="Henry">Carole Henry</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Palm, Anna Karin E" sort="Palm, Anna Karin E" uniqKey="Palm A" first="Anna-Karin E." last="Palm">Anna-Karin E. Palm</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Stamper, Christopher T" sort="Stamper, Christopher T" uniqKey="Stamper C" first="Christopher T." last="Stamper">Christopher T. Stamper</name><affiliation wicri:level="4"><nlm:aff id="A3">The Committee on Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Committee on Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Lan, Linda Yu Ling" sort="Lan, Linda Yu Ling" uniqKey="Lan L" first="Linda Yu-Ling" last="Lan">Linda Yu-Ling Lan</name><affiliation wicri:level="4"><nlm:aff id="A3">The Committee on Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Committee on Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J." last="Topham">David J. Topham</name><affiliation wicri:level="2"><nlm:aff id="A6">Center for Vaccine Biology & Immunology, Department of Microbiology & Immunology, University of Rochester Medical center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vaccine Biology & Immunology, Department of Microbiology & Immunology, University of Rochester Medical center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Treanor, John" sort="Treanor, John" uniqKey="Treanor J" first="John" last="Treanor">John Treanor</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Infectious Disease, Department of Medicine, University of Rochester Medical center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Disease, Department of Medicine, University of Rochester Medical center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wrammert, Jens" sort="Wrammert, Jens" uniqKey="Wrammert J" first="Jens" last="Wrammert">Jens Wrammert</name><affiliation wicri:level="2"><nlm:aff id="A8">Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name><affiliation wicri:level="2"><nlm:aff id="A8">Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Georgiou, George" sort="Georgiou, George" uniqKey="Georgiou G" first="George" last="Georgiou">George Georgiou</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78731, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78731</wicri:regionArea><placeName><region type="state">Texas</region><settlement type="city">Austin (Texas)</settlement></placeName><orgName type="university">Université du Texas à Austin</orgName></affiliation></author><author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. 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uniqKey="Chen Y" first="Yaoqing" last="Chen">Yaoqing Chen</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Wohlbold, Teddy John" sort="Wohlbold, Teddy John" uniqKey="Wohlbold T" first="Teddy John" last="Wohlbold">Teddy John Wohlbold</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zheng, Nai Ying" sort="Zheng, Nai Ying" uniqKey="Zheng N" first="Nai-Ying" last="Zheng">Nai-Ying Zheng</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Huang, Min" sort="Huang, Min" uniqKey="Huang M" first="Min" last="Huang">Min Huang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Huang, Yunping" sort="Huang, Yunping" uniqKey="Huang Y" first="Yunping" last="Huang">Yunping Huang</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Neu, Karlynn E" sort="Neu, Karlynn E" uniqKey="Neu K" first="Karlynn E." last="Neu">Karlynn E. Neu</name><affiliation wicri:level="4"><nlm:aff id="A3">The Committee on Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Committee on Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Lee, Jiwon" sort="Lee, Jiwon" uniqKey="Lee J" first="Jiwon" last="Lee">Jiwon Lee</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78731, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78731</wicri:regionArea><placeName><region type="state">Texas</region><settlement type="city">Austin (Texas)</settlement></placeName><orgName type="university">Université du Texas à Austin</orgName></affiliation></author><author><name sortKey="Wan, Hongquan" sort="Wan, Hongquan" uniqKey="Wan H" first="Hongquan" last="Wan">Hongquan Wan</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Rojas, Karla Thatcher" sort="Rojas, Karla Thatcher" uniqKey="Rojas K" first="Karla Thatcher" last="Rojas">Karla Thatcher Rojas</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Kirkpatrick, Ericka" sort="Kirkpatrick, Ericka" uniqKey="Kirkpatrick E" first="Ericka" last="Kirkpatrick">Ericka Kirkpatrick</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Henry, Carole" sort="Henry, Carole" uniqKey="Henry C" first="Carole" last="Henry">Carole Henry</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Palm, Anna Karin E" sort="Palm, Anna Karin E" uniqKey="Palm A" first="Anna-Karin E." last="Palm">Anna-Karin E. Palm</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Stamper, Christopher T" sort="Stamper, Christopher T" uniqKey="Stamper C" first="Christopher T." last="Stamper">Christopher T. Stamper</name><affiliation wicri:level="4"><nlm:aff id="A3">The Committee on Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Committee on Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Lan, Linda Yu Ling" sort="Lan, Linda Yu Ling" uniqKey="Lan L" first="Linda Yu-Ling" last="Lan">Linda Yu-Ling Lan</name><affiliation wicri:level="4"><nlm:aff id="A3">The Committee on Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Committee on Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author><author><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J." last="Topham">David J. Topham</name><affiliation wicri:level="2"><nlm:aff id="A6">Center for Vaccine Biology & Immunology, Department of Microbiology & Immunology, University of Rochester Medical center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Vaccine Biology & Immunology, Department of Microbiology & Immunology, University of Rochester Medical center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Treanor, John" sort="Treanor, John" uniqKey="Treanor J" first="John" last="Treanor">John Treanor</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Infectious Disease, Department of Medicine, University of Rochester Medical center, Rochester, NY 14642, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Disease, Department of Medicine, University of Rochester Medical center, Rochester, NY 14642</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wrammert, Jens" sort="Wrammert, Jens" uniqKey="Wrammert J" first="Jens" last="Wrammert">Jens Wrammert</name><affiliation wicri:level="2"><nlm:aff id="A8">Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name><affiliation wicri:level="2"><nlm:aff id="A8">Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Emory Vaccine Center, Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Georgiou, George" sort="Georgiou, George" uniqKey="Georgiou G" first="George" last="Georgiou">George Georgiou</name><affiliation wicri:level="4"><nlm:aff id="A4">Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78731, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78731</wicri:regionArea><placeName><region type="state">Texas</region><settlement type="city">Austin (Texas)</settlement></placeName><orgName type="university">Université du Texas à Austin</orgName></affiliation></author><author><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Section of Rheumatology, the Knapp Center for Lupus and Immunology, University of Chicago, Chicago, IL 60637</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de Chicago</orgName></affiliation></author></analytic><series><title level="j">Cell</title><idno type="ISSN">0092-8674</idno><idno type="eISSN">1097-4172</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P1">Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly display key NA epitopes and rarely induce NA-reactive B cells. Conversely, influenza virus infection induces NA-reactive B cells at a frequency that approaches (H1N1) or exceeds (H3N2) that of HA-reactive B cells. NA-reactive antibodies display broad binding activity spanning the entire history of influenza A virus circulation in humans, including the original pandemic strains of both H1N1 and H3N2 subtypes. The antibodies robustly inhibit the enzymatic activity of NA, including oseltamivir-resistant variants, and provide robust prophylactic protection <italic>in vivo</italic>, including against avian H5N1 viruses. When used therapeutically, NA-reactive antibodies protected mice from lethal influenza virus challenge even 48-hours post-infection. These findings strongly suggest that influenza vaccines should be optimized to improve targeting of NA for durable and broad protection against divergent influenza strains.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Illinois</li><li>Maryland</li><li>Texas</li><li>État de New York</li></region><settlement><li>Austin (Texas)</li><li>Chicago</li></settlement><orgName><li>Université de Chicago</li><li>Université du Texas à Austin</li></orgName></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Chen, Yaoqing" sort="Chen, Yaoqing" uniqKey="Chen Y" first="Yaoqing" last="Chen">Yaoqing Chen</name></region><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name><name sortKey="Georgiou, George" sort="Georgiou, George" uniqKey="Georgiou G" first="George" last="Georgiou">George Georgiou</name><name sortKey="Henry, Carole" sort="Henry, Carole" uniqKey="Henry C" first="Carole" last="Henry">Carole Henry</name><name sortKey="Huang, Min" sort="Huang, Min" uniqKey="Huang M" first="Min" last="Huang">Min Huang</name><name sortKey="Huang, Yunping" sort="Huang, Yunping" uniqKey="Huang Y" first="Yunping" last="Huang">Yunping Huang</name><name sortKey="Kirkpatrick, Ericka" sort="Kirkpatrick, Ericka" uniqKey="Kirkpatrick E" first="Ericka" last="Kirkpatrick">Ericka Kirkpatrick</name><name sortKey="Krammer, Florian" sort="Krammer, Florian" uniqKey="Krammer F" first="Florian" last="Krammer">Florian Krammer</name><name sortKey="Lan, Linda Yu Ling" sort="Lan, Linda Yu Ling" uniqKey="Lan L" first="Linda Yu-Ling" last="Lan">Linda Yu-Ling Lan</name><name sortKey="Lee, Jiwon" sort="Lee, Jiwon" uniqKey="Lee J" first="Jiwon" last="Lee">Jiwon Lee</name><name sortKey="Neu, Karlynn E" sort="Neu, Karlynn E" uniqKey="Neu K" first="Karlynn E." last="Neu">Karlynn E. Neu</name><name sortKey="Palm, Anna Karin E" sort="Palm, Anna Karin E" uniqKey="Palm A" first="Anna-Karin E." last="Palm">Anna-Karin E. Palm</name><name sortKey="Rojas, Karla Thatcher" sort="Rojas, Karla Thatcher" uniqKey="Rojas K" first="Karla Thatcher" last="Rojas">Karla Thatcher Rojas</name><name sortKey="Stamper, Christopher T" sort="Stamper, Christopher T" uniqKey="Stamper C" first="Christopher T." last="Stamper">Christopher T. Stamper</name><name sortKey="Topham, David J" sort="Topham, David J" uniqKey="Topham D" first="David J." last="Topham">David J. Topham</name><name sortKey="Treanor, John" sort="Treanor, John" uniqKey="Treanor J" first="John" last="Treanor">John Treanor</name><name sortKey="Wan, Hongquan" sort="Wan, Hongquan" uniqKey="Wan H" first="Hongquan" last="Wan">Hongquan Wan</name><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name><name sortKey="Wohlbold, Teddy John" sort="Wohlbold, Teddy John" uniqKey="Wohlbold T" first="Teddy John" last="Wohlbold">Teddy John Wohlbold</name><name sortKey="Wrammert, Jens" sort="Wrammert, Jens" uniqKey="Wrammert J" first="Jens" last="Wrammert">Jens Wrammert</name><name sortKey="Zheng, Nai Ying" sort="Zheng, Nai Ying" uniqKey="Zheng N" first="Nai-Ying" last="Zheng">Nai-Ying Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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